In vitro screening for population variability in toxicity of pesticide-containing mixtures.

ABSTRACT: Population-based human in vitro models offer exceptional opportunities for evaluating the potential hazard and mode of action of chemicals, as well as variability in responses to toxic insults among individuals. This study was designed to test the hypothesis that comparative population genomics with efficient in vitro experimental design can be used for evaluation of the potential for hazard, mode of action, and the extent of population variability in responses to chemical mixtures. We selected 146 lymphoblast cell lines from 4 ancestrally and geographically diverse human populations based on the availability of genome sequence and basal RNA-seq data. Cells were exposed to two pesticide mixtures - an environmental surface water sample comprised primarily of organochlorine pesticides and a

SUBMITTER: Abdo N 

PROVIDER: S-EPMC4773193 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature