Polycomb dysregulation in gliomagenesis targets a Zfp423-dependent differentiation network.

ABSTRACT: Malignant gliomas constitute one of the most significant areas of unmet medical need, owing to the invariable failure of surgical eradication and their marked molecular heterogeneity. Accumulating evidence has revealed a critical contribution by the Polycomb axis of epigenetic repression. However, a coherent understanding of the regulatory networks affected by Polycomb during gliomagenesis is still lacking. Here we integrate transcriptomic and epigenomic analyses to define Polycomb-dependent networks that promote gliomagenesis, validating them both in two independent mouse models and in a large cohort of human samples. We find that Polycomb dysregulation in gliomagenesis affects transcriptional networks associated with invasiveness and de-differentiation. The dissection of these networks u

SUBMITTER: Signaroldi E 

PROVIDER: S-EPMC4773478 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature