Channelopathy-related SCN10A gene variants predict cerebellar dysfunction in multiple sclerosis.

ABSTRACT:

Objective

To determine the motor-behavioral and neural correlates of putative functional common variants in the sodium-channel NaV1.8 encoding gene (SCN10A) in vivo in patients with multiple sclerosis (MS).

Methods

We recruited 161 patients with relapsing-onset MS and 94 demographically comparable healthy participants. All patients with MS underwent structural MRI and clinical examinations (Expanded Disability Status Scale [EDSS] and Multiple Sclerosis Functional Composite [MSFC]). Whole-brain voxel-wise and cerebellar volumetry were performed to assess differences in regional brain volumes between genotype groups. Resting-state fMRI was acquired from 62 patients with MS to evaluate differences in cerebellar functional connectivity. All participants were genotyped for 4 pote

SUBMITTER: Roostaei T 

PROVIDER: S-EPMC4773947 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature