Modelling the influence of dimerisation sequence dissimilarities on the auxin signalling network.

ABSTRACT:

Background

Auxin is a major phytohormone involved in many developmental processes by controlling gene expression through a network of transcriptional regulators. In Arabidopsis thaliana, the auxin signalling network is made of 52 potentially interacting transcriptional regulators, activating or repressing gene expression. All the possible interactions were tested in two-way yeast-2-hybrid experiments. Our objective was to characterise this auxin signalling network and to quantify the influence of the dimerisation sequence dissimilarities on the interaction between transcriptional regulators.

Results

We applied model-based graph clustering methods relying on connectivity profiles between transcriptional regulators. Incorporating dimerisation sequence dissimilarities as explan

SUBMITTER: Legrand J 

PROVIDER: S-EPMC4774195 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature