Genetic variation affects congenital heart defect susceptibility in offspring exposed to maternal tobacco use.

ABSTRACT:

Background

Congenital heart defects (CHDs) are among the most prevalent and serious birth defects, occurring in 8 to 10 of every 1000 live births in the United States. Epidemiologic studies have reported an association between CHDs and maternal smoking, but it remains unknown how genes impact the susceptibility of offspring to CHDs in the presence of maternal tobacco use.

Methods

Using data from 403 case- and 219 control-parental triads enrolled in the National Birth Defects Prevention Study between 1998 and 2008, we investigated the association between CHDs and maternal and infant genetic variants involved in the tobacco metabolism and DNA repair pathways among mothers who smoked prenatally.

Results

The maternal genotypes of single nucleotide polymorphisms in the exc

SUBMITTER: Tang X 

PROVIDER: S-EPMC4774247 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature