Association of novelty-related behaviors and intravenous cocaine self-administration in Diversity Outbred mice.

ABSTRACT:

Rationale

The preference for and reaction to novelty are strongly associated with addiction to cocaine and other drugs. However, the genetic variants and molecular mechanisms underlying these phenomena remain largely unknown. Although the relationship between novelty- and addiction-related traits has been observed in rats, studies in mice have failed to demonstrate this association. New, genetically diverse, high-precision mouse populations including Diversity Outbred (DO) mice provide an opportunity to assess an expanded range of behavioral variation enabling detection of associations of novelty- and addiction-related traits in mice.

Methods

To examine the relationship between novelty- and addiction-related traits, male (n = 51) and female (n = 47) DO mice were tested on op

SUBMITTER: Dickson PE 

PROVIDER: S-EPMC4774545 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature