Ontology highlight
ABSTRACT:
SUBMITTER: Eleveld TF
PROVIDER: S-EPMC4775079 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Nature genetics 20150629 8
The majority of patients with neuroblastoma have tumors that initially respond to chemotherapy, but a large proportion will experience therapy-resistant relapses. The molecular basis of this aggressive phenotype is unknown. Whole-genome sequencing of 23 paired diagnostic and relapse neuroblastomas showed clonal evolution from the diagnostic tumor, with a median of 29 somatic mutations unique to the relapse sample. Eighteen of the 23 relapse tumors (78%) showed mutations predicted to activate the ...[more]