Loss of Glycogen Debranching Enzyme AGL Drives Bladder Tumor Growth via Induction of Hyaluronic Acid Synthesis.

ABSTRACT:

Purpose

We demonstrated that amylo-alpha-1-6-glucosidase-4-alpha-glucanotransferase (AGL) is a tumor growth suppressor and prognostic marker in human bladder cancer. Here we determine how AGL loss enhances tumor growth, hoping to find therapeutically tractable targets/pathways that could be used in patients with low AGL-expressing tumors.

Experimental design

We transcriptionally profiled bladder cell lines with different AGL expression. By focusing on transcripts overexpressed as a function of low AGL and associated with adverse clinicopathologic variables in human bladder tumors, we sought to increase the chances of discovering novel therapeutic opportunities.

Results

One such transcript was hyaluronic acid synthase 2 (HAS2), an enzyme responsible for hyaluronic acid

SUBMITTER: Guin S 

PROVIDER: S-EPMC4775343 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature