Evolutionary evidence on suitability of SecD as a target for development of antibacterial agents against Staphylococcus aureus.

ABSTRACT: Staphylococcus aureus causes many infections and its drug resistance is a worrying challenge for medical care. The SecD subunit of Sec secretion system in methicillin-resistant S. aureus is an attractive target because SecD dysfunction leads to the death of bacteria and SecD as a target is more efficient than SecA and SecF. Evolution could have made SecD to become insensitive to antibacterial agents although the drugs directly against SecD have yet to develop. So far, no detailed information on SecD evolution has been available, thus 2686 SecD sequences with full taxonomic information from kingdom to species were analyzed. First, the variance of pairwise p-distance was evaluated for each taxonomic group. Second, the variance was further partitioned into intergroup and intragroup variances

SUBMITTER: Yan S 

PROVIDER: S-EPMC4775529 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature