Genetic variants of CDH13 determine the susceptibility to chronic obstructive pulmonary disease in a Chinese population.

ABSTRACT:

Aim

Adiponectin has been implicated in the development of chronic obstructive pulmonary disease (COPD). The CDH13 gene encodes T-cadherin that is an adiponectin receptor, and genetic variants of CDH13 determine blood adiponectin levels. The aim of this study was to investigate the effects of CDH13 variants on COPD susceptibility in a Chinese population.

Methods

Ten single-nucleotide polymorphisms (SNP) in CDH13 were screened using the SNaPshot method in 279 COPD patients and 367 control subjects. Association of genotypes or haplotypes constructed from these loci with COPD was analyzed in different genetic models.

Results

Among the 10 SNPs tested, rs4783244 and rs12922394 exhibited significant differences in allele or genotype frequencies between COPD patients and cont

SUBMITTER: Yuan YM 

PROVIDER: S-EPMC4775852 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature