3DIANA: 3D Domain Interaction Analysis: A Toolbox for Quaternary Structure Modeling.

ABSTRACT: Electron microscopy (EM) is experiencing a revolution with the advent of a new generation of Direct Electron Detectors, enabling a broad range of large and flexible structures to be resolved well below 1 nm resolution. Although EM techniques are evolving to the point of directly obtaining structural data at near-atomic resolution, for many molecules the attainable resolution might not be enough to propose high-resolution structural models. However, accessing information on atomic coordinates is a necessary step toward a deeper understanding of the molecular mechanisms that allow proteins to perform specific tasks. For that reason, methods for the integration of EM three-dimensional maps with x-ray and NMR structural data are being developed, a modeling task that is normally referred to as

SUBMITTER: Segura J 

PROVIDER: S-EPMC4775853 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature