Second malignancies after radiotherapy for prostate cancer: systematic review and meta-analysis.

ABSTRACT:

Objective

To determine the association between exposure to radiotherapy for the treatment of prostate cancer and subsequent second malignancies (second primary cancers).

Design

Systematic review and meta-analysis of observational studies.

Data sources

Medline and Embase up to 6 April 2015 with no restrictions on year or language.

Study selection

Comparative studies assessing the risk of second malignancies in patients exposed or unexposed to radiotherapy in the course of treatment for prostate cancer were selected by two reviewers independently with any disagreement resolved by consensus.

Data extraction and synthesis

Two reviewers independently extracted study characteristics and outcomes. Risk of bias was assessed with the Newcastle-Ottawa scale. Outco

SUBMITTER: Wallis CJ 

PROVIDER: S-EPMC4775870 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature