Ontology highlight
ABSTRACT:
SUBMITTER: Saunders DL
PROVIDER: S-EPMC4775999 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Antimicrobial agents and chemotherapy 20151228 3
Our recent report of dihydroartemisinin-piperaquine failure to treat Plasmodium falciparum infections in Cambodia adds new urgency to the search for alternative treatments. Despite dihydroartemisinin-piperaquine failure, and higher piperaquine 50% inhibitory concentrations (IC50s) following reanalysis than those previously reported, P. falciparum remained sensitive to atovaquone (ATQ) in vitro. There were no point mutations in the P. falciparum cytochrome b ATQ resistance gene. Mefloquine, artem ...[more]