Gold Nanoparticle Conjugation Enhances the Antiacanthamoebic Effects of Chlorhexidine.

ABSTRACT: Acanthamoeba keratitis is a serious infection with blinding consequences and often associated with contact lens wear. Early diagnosis, followed by aggressive topical application of drugs, is a prerequisite in successful treatment, but even then prognosis remains poor. Several drugs have shown promise, including chlorhexidine gluconate; however, host cell toxicity at physiologically relevant concentrations remains a challenge. Nanoparticles, subcolloidal structures ranging in size from 10 to 100 nm, are effective drug carriers for enhancing drug potency. The overall aim of the present study was to determine whether conjugation with gold nanoparticles enhances the antiacanthamoebic potential of chlorhexidine. Gold-conjugated chlorhexidine nanoparticles were synthesized. Briefly, gold solutio

SUBMITTER: Aqeel Y 

PROVIDER: S-EPMC4776020 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature