Variations in Fusion Pore Formation in Cholesterol-Treated Platelets.

ABSTRACT: Exocytosis is a highly regulated intercellular communication process involving various membrane proteins, lipids, and cytoskeleton restructuring. These components help control granule fusion with the cell membrane, creating a pore through which granular contents are released into the extracellular environment. Platelets are an ideal model system for studying exocytosis due to their lack of a nucleus, resulting in decreased membrane regulation in response to cellular changes. In addition, platelets contain fewer granules than most other exocytosing cells, allowing straightforward measurement of individual granule release with carbon-fiber microelectrode amperometry. This technique monitors the concentration of serotonin, an electroactive molecule found in the dense-body granules of platelet

SUBMITTER: Finkenstaedt-Quinn SA 

PROVIDER: S-EPMC4776030 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature