White Matter Abnormalities in Post-traumatic Stress Disorder Following a Specific Traumatic Event.

ABSTRACT: Studies of posttraumatic stress disorder (PTSD) are complicated by wide variability in the intensity and duration of prior stressors in patient participants, secondary effects of chronic psychiatric illness, and a variable history of treatment with psychiatric medications. In magnetic resonance imaging (MRI) studies, patient samples have often been small, and they were not often compared to similarly stressed patients without PTSD in order to control for general stress effects. Findings from these studies have been inconsistent. The present study investigated whole-brain microstructural alterations of white matter in a large drug-naive population who survived a specific, severe traumatic event (a major 8.0-magnitude earthquake). Using diffusion tensor imaging (DTI), we explored group diffe

SUBMITTER: Li L 

PROVIDER: S-EPMC4776058 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature