Gene by Environment Investigation of Incident Lung Cancer Risk in African-Americans.

ABSTRACT:

Background

Genome-wide association studies have identified polymorphisms linked to both smoking exposure and risk of lung cancer. The degree to which lung cancer risk is driven by increased smoking, genetics, or gene-environment interactions is not well understood.

Methods

We analyzed associations between 28 single nucleotide polymorphisms (SNPs) previously associated with smoking quantity and lung cancer in 7156 African-American females in the Women's Health Initiative (WHI), then analyzed main effects of top nominally significant SNPs and interactions between SNPs, cigarettes per day (CPD) and pack-years for lung cancer in an independent, multi-center case-control study of African-American females and males (1078 lung cancer cases and 822 controls).

Findings

Nine no

SUBMITTER: David SP 

PROVIDER: S-EPMC4776066 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature