HIV, antiretroviral treatment, hypertension, and stroke in Malawian adults: A case-control study.

ABSTRACT:

Objective

To investigate HIV, its treatment, and hypertension as stroke risk factors in Malawian adults.

Methods

We performed a case-control study of 222 adults with acute stroke, confirmed by MRI in 86%, and 503 population controls, frequency-matched for age, sex, and place of residence, using Global Positioning System for random selection. Multivariate logistic regression models were used for case-control comparisons.

Results

HIV infection (population attributable fraction [PAF] 15%) and hypertension (PAF 46%) were strongly linked to stroke. HIV was the predominant risk factor for young stroke (≤45 years), with a prevalence of 67% and an adjusted odds ratio (aOR) (95% confidence interval) of 5.57 (2.43-12.8) (PAF 42%). There was an increased risk of a stroke in pati

SUBMITTER: Benjamin LA 

PROVIDER: S-EPMC4776088 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature