Shared genetic susceptibility of vascular-related biomarkers with ischemic and recurrent stroke.

ABSTRACT:

Objective

To investigate the genetic contributors to cerebrovascular disease and variation in biomarkers of ischemic stroke.

Methods

The Vitamin Intervention for Stroke Prevention Trial (VISP) was a randomized, controlled clinical trial of B vitamin supplementation to prevent recurrent stroke, myocardial infarction, or death. VISP collected baseline measures of C-reactive protein (CRP), fibrinogen, creatinine, prothrombin fragments F1+2, thrombin-antithrombin complex, and thrombomodulin prior to treatment initiation. Genome-wide association scans were conducted for these traits and follow-up replication analyses were performed.

Results

We detected an association between CRP single nucleotide polymorphisms (SNPs) and circulating CRP levels (most associated SNP, rs25929

SUBMITTER: Williams SR 

PROVIDER: S-EPMC4776093 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature