Predicted molecular signaling guiding photoreceptor cell migration following transplantation into damaged retina.

ABSTRACT: To replace photoreceptors lost to disease or trauma and restore vision, laboratories around the world are investigating photoreceptor replacement strategies using subretinal transplantation of photoreceptor precursor cells (PPCs) and retinal progenitor cells (RPCs). Significant obstacles to advancement of photoreceptor cell-replacement include low migration rates of transplanted cells into host retina and an absence of data describing chemotactic signaling guiding migration of transplanted cells in the damaged retinal microenvironment. To elucidate chemotactic signaling guiding transplanted cell migration, bioinformatics modeling of PPC transplantation into light-damaged retina was performed. The bioinformatics modeling analyzed whole-genome expression data and matched PPC chemotactic cell

SUBMITTER: Unachukwu UJ 

PROVIDER: S-EPMC4776098 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature