Unknown

Dataset Information

0

Most microbe-specific naive CD4? T cells produce memory cells during infection.


ABSTRACT: Infection elicits CD4(+) memory T lymphocytes that participate in protective immunity. Although memory cells are the progeny of naïve T cells, it is unclear that all naïve cells from a polyclonal repertoire have memory cell potential. Using a single-cell adoptive transfer and spleen biopsy method, we found that in mice, essentially all microbe-specific naïve cells produced memory cells during infection. Different clonal memory cell populations had different B cell or macrophage helper compositions that matched effector cell populations generated much earlier in the response. Thus, each microbe-specific naïve CD4(+) T cell produces a distinctive ratio of effector cell types early in the immune response that is maintained as some cells in the clonal population become memory cells.

SUBMITTER: Tubo NJ 

PROVIDER: S-EPMC4776317 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature

altmetric image

Publications

Most microbe-specific naïve CD4⁺ T cells produce memory cells during infection.

Tubo Noah J NJ   Fife Brian T BT   Pagan Antonio J AJ   Kotov Dmitri I DI   Goldberg Michael F MF   Jenkins Marc K MK  

Science (New York, N.Y.) 20160101 6272


Infection elicits CD4(+) memory T lymphocytes that participate in protective immunity. Although memory cells are the progeny of naïve T cells, it is unclear that all naïve cells from a polyclonal repertoire have memory cell potential. Using a single-cell adoptive transfer and spleen biopsy method, we found that in mice, essentially all microbe-specific naïve cells produced memory cells during infection. Different clonal memory cell populations had different B cell or macrophage helper compositio  ...[more]

Similar Datasets

| S-EPMC7580951 | biostudies-literature
| S-EPMC5974168 | biostudies-literature
| S-SCDT-10_15252-EMMM_202317713 | biostudies-other
| S-EPMC6112860 | biostudies-literature
| S-EPMC10701605 | biostudies-literature
| S-EPMC3997369 | biostudies-literature
| S-EPMC4076590 | biostudies-literature
| S-EPMC58783 | biostudies-literature
| S-EPMC3608733 | biostudies-literature
| S-EPMC5477126 | biostudies-literature