Viral suppression in adolescents on antiretroviral treatment: review of the literature and critical appraisal of methodological challenges.

ABSTRACT:

Objective

Medication adherence is often suboptimal for adolescents with HIV, and establishing correct weight-based antiretroviral therapy dosing is difficult, contributing to virological failure. This review aimed to determine the proportion of adolescents achieving virological suppression after initiating ART.

Methods

MEDLINE, EMBASE and Web of Science databases were searched. Studies published between January 2004 and September 2014 including ≥50 adolescents taking ART and reporting on the proportion of virological suppressed participants were included.

Results

From a total of 5316 potentially relevant citations, 20 studies were included. Only eight studies reported the proportion of adolescents that were virologically suppressed at a specified time point. The propo

SUBMITTER: Ferrand RA 

PROVIDER: S-EPMC4776345 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature