GWASeq: targeted re-sequencing follow up to GWAS.

ABSTRACT:

Background

For the last decade the conceptual framework of the Genome-Wide Association Study (GWAS) has dominated the investigation of human disease and other complex traits. While GWAS have been successful in identifying a large number of variants associated with various phenotypes, the overall amount of heritability explained by these variants remains small. This raises the question of how best to follow up on a GWAS, localize causal variants accounting for GWAS hits, and as a consequence explain more of the so-called "missing" heritability. Advances in high throughput sequencing technologies now allow for the efficient and cost-effective collection of vast amounts of fine-scale genomic data to complement GWAS.

Results

We investigate these issues using a colon cancer datas

SUBMITTER: Salomon MP 

PROVIDER: S-EPMC4776370 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature