Genome dynamics of multidrug-resistant Acinetobacter baumannii during infection and treatment.

ABSTRACT:

Background

Limited treatment options are available for patients infected with multidrug (MDR)- or pan-drug (PDR)-resistant bacterial pathogens, resulting in infections that can persist for weeks or months. In order to better understand transmission and evolutionary dynamics of MDR Acinetobacter baumannii (Ab) during long-term infection, we analyzed genomes from a series of isolates from individual patients at isolate-specific, patient-specific, and population levels.

Methods

Whole genome analysis of longitudinal isolates (range 2-10 isolates per patient spanning 0-829 days) from 40 patients included detection of single-nucleotide variants (SNVs), insertion sequence (IS) mapping, and gene content changes.

Results

Phylogenetic analysis revealed that a significant fracti

SUBMITTER: Wright MS 

PROVIDER: S-EPMC4776386 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature