Genetic susceptibility for cow's milk allergy in Dutch children: the start of the allergic march?

ABSTRACT:

Background

Cow's milk allergy (CMA) is the most common allergic disease in infancy. It is not clear, whether infants with CMA have an increased risk of developing other allergic diseases later in life, the so-called "allergic march". We aimed to detect genetic associations of CMA using reported single nucleotide polymorphisms (SNP) in other allergic diseases and genetic mutations within the filaggrin (FLG) gene. Both to investigate possible causes of CMA, which also suggests an "allergic march".

Methods

Thirty children from the Dutch EuroPrevall birth cohort study with CMA in infancy and twenty-three healthy controls were studied. Six candidate SNPs were selected (minor allele frequency 10-50 % combined with a large effect) based on the literature. Thirteen FLG candidate mut

SUBMITTER: Henneman P 

PROVIDER: S-EPMC4776421 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature