Degradation of the electrospun silica nanofiber in a biological medium for primary hippocampal neuron - effect of surface modification.

ABSTRACT: In this work, silica nanofibers (SNFs) were prepared by an electrospinning method and modified with poly-d-lysine (PDL) or (3-aminopropyl) trimethoxysilane (APTS) making biocompatible and degradable substrates for neuronal growth. The as-prepared SNF, modified SNF-PDL, and SNF-APTS were evaluated using scanning electron microscopy, nitrogen adsorption/desorption isotherms, contact angle measurements, and inductively coupled plasma atomic emission spectroscopy. Herein, the scanning electron microscopic images revealed that dissolution occurred in a corrosion-like manner by enlarging porous structures, which led to loss of structural integrity. In addition, covalently modified SNF-APTS with more hydrophobic surfaces and smaller surface areas resulted in significantly slower dissolution compa

SUBMITTER: Feng ZV 

PROVIDER: S-EPMC4777233 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature