Role of RDS and Rhodopsin in Cngb1-Related Retinal Degeneration.

ABSTRACT:

Purpose

Rod photoreceptor outer segment (OS) morphogenesis, structural integrity, and proper signal transduction rely on critical proteins found in the different OS membrane domains (e.g., plasma, disc, and disc rim membrane). Among these key elements are retinal degeneration slow (RDS, also known as peripherin-2), rhodopsin, and the beta subunit of the cyclic nucleotide gated channel (CNGB1a), which have been found to interact in a complex. The purpose of this study was to evaluate the potential interplay between these three proteins by examining retinal disease phenotypes in animal models expressing varying amounts of CNGB1a, rhodopsin, and RDS.

Methods

Outer segment trafficking, retinal function, and photoreceptor structure were evaluated using knockout mouse lines.

Re

SUBMITTER: Chakraborty D 

PROVIDER: S-EPMC4777275 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature