Ontology highlight
ABSTRACT:
SUBMITTER: Yan X
PROVIDER: S-EPMC4777353 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Cancer cell 20151001 4
The discovery of long non-coding RNA (lncRNA) has dramatically altered our understanding of cancer. Here, we describe a comprehensive analysis of lncRNA alterations at transcriptional, genomic, and epigenetic levels in 5,037 human tumor specimens across 13 cancer types from The Cancer Genome Atlas. Our results suggest that the expression and dysregulation of lncRNAs are highly cancer type specific compared with protein-coding genes. Using the integrative data generated by this analysis, we prese ...[more]