Stability and Competition in Multi-spike Models of Spike-Timing Dependent Plasticity.

ABSTRACT: Spike-timing dependent plasticity (STDP) is a widespread plasticity mechanism in the nervous system. The simplest description of STDP only takes into account pairs of pre- and postsynaptic spikes, with potentiation of the synapse when a presynaptic spike precedes a postsynaptic spike and depression otherwise. In light of experiments that explored a variety of spike patterns, the pair-based STDP model has been augmented to account for multiple pre- and postsynaptic spike interactions. As a result, a number of different "multi-spike" STDP models have been proposed based on different experimental observations. The behavior of these models at the population level is crucial for understanding mechanisms of learning and memory. The challenging balance between the stability of a population of syn

SUBMITTER: Babadi B 

PROVIDER: S-EPMC4777380 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature