A Systematic Investigation into Aging Related Genes in Brain and Their Relationship with Alzheimer's Disease.

ABSTRACT: Aging, as a complex biological process, is accompanied by the accumulation of functional loses at different levels, which makes age to be the biggest risk factor to many neurological diseases. Even following decades of investigation, the process of aging is still far from being fully understood, especially at a systematic level. In this study, we identified aging related genes in brain by collecting the ones with sustained and consistent gene expression or DNA methylation changes in the aging process. Functional analysis with Gene Ontology to these genes suggested transcriptional regulators to be the most affected genes in the aging process. Transcription regulation analysis found some transcription factors, especially Specificity Protein 1 (SP1), to play important roles in regulating agin

SUBMITTER: Meng G 

PROVIDER: S-EPMC4777381 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature