Rates of Hydroxyl Radical Production from Transition Metals and Quinones in a Surrogate Lung Fluid.

ABSTRACT: Hydroxyl radical ((•)OH) is the most reactive, and perhaps most detrimental to health, of the reactive oxygen species. (•)OH production in lungs following inhalation of particulate matter (PM) can result from redox-active chemicals, including iron and copper, but the relative importance of these species is unknown. This work investigates (•)OH production from iron, copper, and quinones, both individually and in mixtures at atmospherically relevant concentrations. Iron, copper, and three of the four quinones (1,2-naphthoquinone, phenanthrenequinone and 1,4-naphthoquinone) produce (•)OH. Mixtures of copper or quinones with iron synergistically produce (•)OH at a rate 20-130% higher than the sum of the rates of the individual redox-active species. We developed a regression equation from 20 mi

SUBMITTER: Charrier JG 

PROVIDER: S-EPMC4777526 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature