Large-scale intrinsic functional network organization along the long axis of the human medial temporal lobe.

ABSTRACT: The medial temporal lobe (MTL), encompassing the hippocampus and parahippocampal gyrus (PHG), is a heterogeneous structure which plays a critical role in memory and cognition. Here, we investigate functional architecture of the human MTL along the long axis of the hippocampus and PHG. The hippocampus showed stronger connectivity with striatum, ventral tegmental area and amygdala-regions important for integrating reward and affective signals, whereas the PHG showed stronger connectivity with unimodal and polymodal association cortices. In the hippocampus, the anterior node showed stronger connectivity with the anterior medial temporal lobe and the posterior node showed stronger connectivity with widely distributed cortical and subcortical regions including those involved in sensory and rewa

SUBMITTER: Qin S 

PROVIDER: S-EPMC4777679 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature