Cerebrospinal fluid ratios with Aβ42 predict preclinical brain β-amyloid accumulation.

ABSTRACT:

Introduction

Biomarkers are urgently needed for the critical yet understudied preclinical stage of Alzheimer's disease (AD).

Methods

CSF collection, [C-11]PiB amyloid imaging, and MRI were acquired in n=104 cognitively healthy adults enriched with risk for sporadic AD. Image-derived cerebral β-amyloid (Aβ) burden, measured concurrently and longitudinally, was regressed on CSF measures of Aβ, neural injury, and inflammation, as well as ratios with Aβ₄₂. Linear mixed effects regression was used to model the effect of the CSF measures that predicted longitudinal brain amyloid accumulation on longitudinal cognitive decline, measured by memory test scores.

Results

At baseline, Aβ₄₂/Aβ₄₀ and all CSF ratios to Aβ₄₂ were associated

SUBMITTER: Racine AM 

PROVIDER: S-EPMC4778249 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature