Increased caveolin-1 in intervertebral disc degeneration facilitates repair.

ABSTRACT:

Background

Preceding intervertebral disc (IVD) degeneration, the cell phenotype in the nucleus pulposus (NP) shifts from notochordal cells (NCs) to chondrocyte-like cells (CLCs). Microarray analysis showed a correlation between caveolin-1 expression and the phenotypic transition of NCs to CLCs. With a clinical directive in mind, the aim of this study was to determine the role of caveolin-1 in IVD degeneration. As a scaffolding protein, caveolin-1 influences several signaling pathways, and transforming growth factor (TGF)-β receptors have been demonstrated to colocalize with caveolin-1. Therefore, the hypothesis of this study was that caveolin-1 facilitates repair by enhancing TGF-β signaling in the IVD.

Methods

Protein expression (caveolin-1, apoptosis, progenitor cell marke

SUBMITTER: Bach FC 

PROVIDER: S-EPMC4778307 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature