Ontology highlight
ABSTRACT:
SUBMITTER: Masuda T
PROVIDER: S-EPMC4778394 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20160101 6270
Genes encoding human β-type globin undergo a developmental switch from embryonic to fetal to adult-type expression. Mutations in the adult form cause inherited hemoglobinopathies or globin disorders, including sickle cell disease and thalassemia. Some experimental results have suggested that these diseases could be treated by induction of fetal-type hemoglobin (HbF). However, the mechanisms that repress HbF in adults remain unclear. We found that the LRF/ZBTB7A transcription factor occupies feta ...[more]