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Asymmetric α-amination of β-keto esters using a guanidine-bisurea bifunctional organocatalyst.

ABSTRACT: An asymmetric α-amination of β-keto esters with azodicarboxylate in the presence of a guanidine-bisurea bifunctional organocatalyst was investigated. The α-amination products were obtained in up to 99% yield with up to 94% ee.

SUBMITTER: Odagi M

PROVIDER: S-EPMC4778535 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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Asymmetric α-amination of β-keto esters using a guanidine-bisurea bifunctional organocatalyst.

Odagi Minami M Yamamoto Yoshiharu Y Nagasawa Kazuo K

Beilstein journal of organic chemistry 20160204

An asymmetric α-amination of β-keto esters with azodicarboxylate in the presence of a guanidine-bisurea bifunctional organocatalyst was investigated. The α-amination products were obtained in up to 99% yield with up to 94% ee. ...[more]

PMID: 26977179

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