Demographically-Based Evaluation of Genomic Regions under Selection in Domestic Dogs.

ABSTRACT: Controlling for background demographic effects is important for accurately identifying loci that have recently undergone positive selection. To date, the effects of demography have not yet been explicitly considered when identifying loci under selection during dog domestication. To investigate positive selection on the dog lineage early in the domestication, we examined patterns of polymorphism in six canid genomes that were previously used to infer a demographic model of dog domestication. Using an inferred demographic model, we computed false discovery rates (FDR) and identified 349 outlier regions consistent with positive selection at a low FDR. The signals in the top 100 regions were frequently centered on candidate genes related to brain function and behavior, including LHFPL3, CADM2,

SUBMITTER: Freedman AH 

PROVIDER: S-EPMC4778760 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature