Clinical efficacy and safety of T-DM1 for patients with HER2-positive breast cancer.

ABSTRACT:

Purpose

The aim of this study was to evaluate the therapeutic efficacy and safety of trastuzumab emtansine (T-DM1) for the treatment of patients with human epidermal growth factor receptor 2-positive breast cancer.

Methods

We performed a systemic review and meta-analysis of the relevant published clinical studies. A computerized search was performed for controlled clinical trials of T-DM1 in targeted treatment. Overall survival, progression-free survival, objective response rate, symptom progression free, and adverse events (AEs) were evaluated.

Results

Eight eligible trials with a total of 2,016 patients with breast cancer were included in the present meta-analysis. The treatment of patients with breast cancer with T-DM1 was associated with significantly increased ov

SUBMITTER: Ma B 

PROVIDER: S-EPMC4778787 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature