Reconstruction of Tissue-Specific Metabolic Networks Using CORDA.

ABSTRACT: Human metabolism involves thousands of reactions and metabolites. To interpret this complexity, computational modeling becomes an essential experimental tool. One of the most popular techniques to study human metabolism as a whole is genome scale modeling. A key challenge to applying genome scale modeling is identifying critical metabolic reactions across diverse human tissues. Here we introduce a novel algorithm called Cost Optimization Reaction Dependency Assessment (CORDA) to build genome scale models in a tissue-specific manner. CORDA performs more efficiently computationally, shows better agreement to experimental data, and displays better model functionality and capacity when compared to previous algorithms. CORDA also returns reaction associations that can greatly assist in any manu

SUBMITTER: Schultz A 

PROVIDER: S-EPMC4778931 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature