Differences in Gene-Gene Interactions in Graves' Disease Patients Stratified by Age of Onset.

ABSTRACT:

Background

Graves' disease (GD) is a complex disease in which genetic predisposition is modified by environmental factors. Each gene exerts limited effects on the development of autoimmune disease (OR = 1.2-1.5). An epidemiological study revealed that nearly 70% of the risk of developing inherited autoimmunological thyroid diseases (AITD) is the result of gene interactions. In the present study, we analyzed the effects of the interactions of multiple loci on the genetic predisposition to GD. The aim of our analyses was to identify pairs of genes that exhibit a multiplicative interaction effect.

Material and methods

A total of 709 patients with GD were included in the study. The patients were stratified into more homogeneous groups depending on the age at time of GD onset: yo

SUBMITTER: Jurecka-Lubieniecka B 

PROVIDER: S-EPMC4778933 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature