Joint Model of Iron and Hepcidin During the Menstrual Cycle in Healthy Women.

ABSTRACT: Hepcidin regulates serum iron levels, and its dosage is used in differential diagnostic of iron-related pathologies. We used the data collected in the HEPMEN (named after HEPcidin during MENses) study to investigate the joint dynamics of serum hepcidin and iron during the menstrual cycle in healthy women. Ninety menstruating women were recruited after a screening visit. Six fasting blood samples for determination of iron-status variables were taken in the morning throughout the cycle, starting on the second day of the period. Non-linear mixed effect models were used to describe the evolution of iron and hepcidin. Demographic and medical covariates were tested for their effect on model parameters. Parameter estimation was performed using the SAEM algorithm implemented in the Monolix softwar

SUBMITTER: Angeli A 

PROVIDER: S-EPMC4779110 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature