Accuracy of circulating adiponectin for predicting gestational diabetes: a systematic review and meta-analysis.

ABSTRACT:

Aims/hypothesis

Universal screening for gestational diabetes mellitus (GDM) has not been implemented, and this has had substantial clinical implications. Biomarker-directed targeted screening might be feasible. We sought to determine the accuracy of circulating adiponectin for early prediction of GDM.

Methods

A systematic review and meta-analysis of the literature to May 2015 identified studies in which circulating adiponectin was measured prior to a diagnosis of GDM. Data on diagnostic accuracy were synthesised by bivariate mixed effects and hierarchical summary receiver operating characteristic (HSROC) models.

Results

Thirteen studies met the eligibility criteria, 11 of which (2,865 women; 794 diagnosed with GDM) had extractable data. Circulating adiponectin had a p

SUBMITTER: Iliodromiti S 

PROVIDER: S-EPMC4779132 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature