Kinase programs spatiotemporally regulate gap junction assembly and disassembly: Effects on wound repair.

ABSTRACT: Gap junctions are highly ordered plasma membrane domains that are constantly assembled, remodeled and turned over due to the short half-life of connexins, the integral membrane proteins that form gap junctions. Connexin 43 (Cx43), by far the most widely expressed connexin, is phosphorylated at multiple serine residues in the cytoplasmic, C-terminal region allowing for exquisite cellular control over gap junctional communication. This is evident during epidermal wounding where spatiotemporal changes in connexin expression occur as cells are instructed whether to die, proliferate or migrate to promote repair. Early gap junctional communication is required for initiation of keratinocyte migration, but accelerated Cx43 turnover is also critical for proper wound healing at later stages. These e

SUBMITTER: Solan JL 

PROVIDER: S-EPMC4779375 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature