Adaptive Servo-Ventilation for Central Sleep Apnea in Systolic Heart Failure.

ABSTRACT:

Background

Central sleep apnea is associated with poor prognosis and death in patients with heart failure. Adaptive servo-ventilation is a therapy that uses a noninvasive ventilator to treat central sleep apnea by delivering servo-controlled inspiratory pressure support on top of expiratory positive airway pressure. We investigated the effects of adaptive servo-ventilation in patients who had heart failure with reduced ejection fraction and predominantly central sleep apnea.

Methods

We randomly assigned 1325 patients with a left ventricular ejection fraction of 45% or less, an apnea-hypopnea index (AHI) of 15 or more events (occurrences of apnea or hypopnea) per hour, and a predominance of central events to receive guideline-based medical treatment with adaptive servo-ventil

SUBMITTER: Cowie MR 

PROVIDER: S-EPMC4779593 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature