Preventing ICU Subsyndromal Delirium Conversion to Delirium With Low-Dose IV Haloperidol: A Double-Blind, Placebo-Controlled Pilot Study.

ABSTRACT:

Objective

To compare the efficacy and safety of scheduled low-dose haloperidol versus placebo for the prevention of delirium (Intensive Care Delirium Screening Checklist ≥ 4) administered to critically ill adults with subsyndromal delirium (Intensive Care Delirium Screening Checklist = 1-3).

Design

Randomized, double-blind, placebo-controlled trial.

Setting

Three 10-bed ICUs (two medical and one surgical) at an academic medical center in the United States.

Patients

Sixty-eight mechanically ventilated patients with subsyndromal delirium without complicating neurologic conditions, cardiac surgery, or requiring deep sedation.

Interventions

Patients were randomly assigned to receive IV haloperidol 1 mg or placebo every 6 hours until delirium occurred (Intens

SUBMITTER: Al-Qadheeb NS 

PROVIDER: S-EPMC4779647 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature