Investigation of Exomic Variants Associated with Overall Survival in Ovarian Cancer.

ABSTRACT:

Background

While numerous susceptibility loci for epithelial ovarian cancer (EOC) have been identified, few associations have been reported with overall survival. In the absence of common prognostic genetic markers, we hypothesize that rare coding variants may be associated with overall EOC survival and assessed their contribution in two exome-based genotyping projects of the Ovarian Cancer Association Consortium (OCAC).

Methods

The primary patient set (Set 1) included 14 independent EOC studies (4,293 patients) and 227,892 variants, and a secondary patient set (Set 2) included six additional EOC studies (1,744 patients) and 114,620 variants. Because power to detect rare variants individually is reduced, gene-level tests were conducted. Sets were analyzed separately at indiv

SUBMITTER: Winham SJ 

PROVIDER: S-EPMC4779669 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature