Effectiveness of semen washing to prevent human immunodeficiency virus (HIV) transmission and assist pregnancy in HIV-discordant couples: a systematic review and meta-analysis.

ABSTRACT:

Objective

To evaluate the effectiveness of semen washing in human immunodeficiency virus (HIV)-discordant couples in which the male partner is infected.

Design

Systematic review and meta-analysis.

Setting

Not applicable.

Patient(s)

Forty single-arm open-label studies among HIV-discordant couples that underwent intrauterine insemination (IUI) or in vitro fertilization (IVF) with or without intracytoplasmic sperm injection (ICSI) using washed semen.

Intervention(s)

Semen washing followed by IUI, IVF, or IVF/ICSI.

Main outcome measure(s)

Primary outcome

HIV transmission to HIV-uninfected women; secondary outcomes: HIV transmission to newborns and proportion of couples achieving a clinical pregnancy.

Result(s)

No HIV transmission occurr

SUBMITTER: Zafer M 

PROVIDER: S-EPMC4779710 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature