A prognostic model based on readily available clinical data enriched a pre-emptive pharmacogenetic testing program.

ABSTRACT:

Objectives

We describe the development, implementation, and evaluation of a model to pre-emptively select patients for genotyping based on medication exposure risk.

Study design and setting

Using deidentified electronic health records, we derived a prognostic model for the prescription of statins, warfarin, or clopidogrel. The model was implemented into a clinical decision support (CDS) tool to recommend pre-emptive genotyping for patients exceeding a prescription risk threshold. We evaluated the rule on an independent validation cohort and on an implementation cohort, representing the population in which the CDS tool was deployed.

Results

The model exhibited moderate discrimination with area under the receiver operator characteristic curves ranging from 0.68 to 0.75

SUBMITTER: Schildcrout JS 

PROVIDER: S-EPMC4779720 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature