Differential Serum Cytokine Levels and Risk of Lung Cancer Between African and European Americans.

ABSTRACT:

Background

African Americans have a higher risk of developing lung cancer than European Americans. Previous studies suggested that certain circulating cytokines were associated with lung cancer. We hypothesized that variations in serum cytokine levels exist between African Americans and European Americans, and increased circulating cytokine levels contribute to lung cancer differently in the two races.

Methods

Differences in 10 serum cytokine levels, IL1β, IL4, IL5, IL6, IL8, IL10, IL12, granulocyte macrophage colony-stimulating factor, IFNγ, and TNFα, between 170 African-American and 296 European-American controls from the National Cancer Institute-Maryland (NCI-MD) case-control study were assessed. Associations of the serum cytokine levels with lung cancer were analyzed. S

SUBMITTER: Pine SR 

PROVIDER: S-EPMC4779723 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature