Active opioid use does not attenuate the humoral responses to inactivated influenza vaccine.

ABSTRACT:

Background

Influenza vaccination is recommended for vulnerable individuals, including active drug users, to prevent influenza complications and decrease influenza spread. Recent studies suggest that opioids negatively regulate immune responses in experimental models, but the extent to which opioid use will affect the humoral responses to influenza vaccine in humans is unknown. This information is critical in maximizing vaccination efforts.

Objective

To determine whether there is a difference in antibody response after influenza vaccination in heroin or methadone users compared to control subjects.

Methods

We studied active heroin users, subjects on methadone maintenance treatment (MMT) and subjects that did not use any drugs before and 1 and 4 weeks after vaccination

SUBMITTER: Moroz E 

PROVIDER: S-EPMC4780674 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature